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Parameters
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Mean
|
SD
|
Physiological values and references
|
|---|
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Mean ECF Volume (ml/100 g)
|
22.6
|
0.6
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≈21.9** [10]; 22.3 ± 0.8 [49] ≈23.7** [50]; ≈23.1 [12]; 23.2 ± 2.4 [51]; 24 ± 2 [52]
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|
Mean ECF [Na+] (mmol/L)
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142.2
|
0.7
|
138 ± 2.6 [22]; 140 ± 3 [53]; 141 ± 2 [46]; 141.6 ± 0.3 [54]; 142 ± 1 [55]; 143.3 ± 0.4 [37]; 129 to 150 [17]
|
|
Mean AVP (pg/ml) during the maintenance phase
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1.7
|
0.9
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1.1 ± 0.21 [56]; 1.7 ± 0.3 [23]; 1.8 ± 0.3 [54]; 1.9 ± 1.1 [46]; 2.3 ± 0.9 [20]; 2.5 ± 1.3 [53]
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|
Urine Volume (ml/100 g)
|
11.8
|
3.4
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10.8 ± 3.6 [57]; 8.9 ± 5.9 [17]; 13 [19]; 13 ± 2 [58]; 14 ± 1 [34]
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|
Water intake (ml/100 g)
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18.0
|
3.7
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15.2 ± 1.8 [10]; ≈16 [38]; 20 ± 3 [58]
|
|
Na+ intake (mmol/100 g)
|
0.69
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0.17
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≈0.75 [59]; 0.84 ± 0.02 [34]; 0.97 ± 0.14 [23]
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Mean ICF Volume (ml/100 g)
|
45.3
|
0.3
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≈ 45.9 [12]; 45 ± 1 [50]**; 44.5 ± 3.1** [51]; ≈ 44.6 [10]; 50 ± 5** [52]
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- Daily mean and standard deviation of each parameter are obtained after 20 consecutive days of simulation under control conditions. All the predictions are coherent with experimental data reported in the literature according to their deviations. Some experimental data had to be normalized for comparison. The "**" symbol indicates that the value was obtained by subtracting the ICF or ECF volume of the model from the total water content of the rat measured experimentally.
