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Table 3 Predictions of the hydromineral parameters obtained with the simulated extracellular dehydration protocol (furosemide injections combined with a Na+ deficient diet).

From: Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis

Parameters First 4 h (day 0)
Control
First 4 h (day 1)
Extracellular dehydration
24 h (day 0)
Control
24 h (day 1)
Extracellular dehydration
Mean ECF [Na+] over the period (mmol/L) 141.6 146.8 141.8 141.3
Mean [AVP] (pg/ml) 2.2 4.5 2.7 4.8
Mean ECF Volume (ml/100 g) 22.7 22.0 22.7 21.7
Mean ICF Volume (ml/100 g) 45.5 44.0 45.4 45.6
ECF [Na+] at the end of the period (mmol/L) 141.8 149.9 142.2 134.0
Cumulative Urine Na+ (mmol/100 g) 0.1 0.3 0.83 1.19
Water intake (ml/100 g) 0.1 3.5* 18.2 20.3
Na+ intake (mmol/100 g) 0.0072 0 0.74 0.41
Urine Volume (ml/100 g) 1.8 4.1 12.4 12.8
  1. Predictions at different time-points (4 h and 24 h) under control condition are listed under day 0 and predictions under Na+ deficit are listed under day 1. "*" indicates the amount of water ingested during the first 4 h after access to tap water (see the method for a detailed description of the protocol).