Figure 8

Densitometry analysis of IGF-I receptor expression. Ambulatory IGF-I and GH+IGF-I treated animals showed a strong trend of increased IGF-I receptor expression, however, this trend was not significant. In hindlimb unloaded animals treated with IGF-I or GH+IGF-I, IGF-I receptor expression was significantly increased compared to saline treated hindlimb unloaded animals, indicating a possible role for localized increases in IGF-I receptor to play a role in mediating improvements seen in the structure and function of treated ligaments.