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Table 2 Tubular effects of the AT1R antagonist ZD 7155 in conscious lambs

From: Renal effects of angiotensin II in the newborn period: role of type 1 and type 2 receptors

Variable One week Six weeks
Control 30 min 60 min Control 30 min 60 min
CNa (μL · g−1 · min−1) 0.24 ± 0.05 0.18 ± 0.08 0.21 ± 0.16 0.90 ± 0.52** 0.94 ± 0.42** 0.62 ± 0.29**,*
FRNa % 99.93 ± 0.03 99.90 ± 0.08 99.73 ± 0.60 99.90 ± 0.12 99.84 ± 0.23 99.89 ± 0.12
PRNa % 78.3 ± 8.8 81.8 ± 9.1 84.1 ± 10.8 70.4 ± 19.1** 69.4 ± 21.1** 70.1 ± 15.6**
DRNa % 21.7 ± 8.8 18.1 ± 9.1 15.6 ± 10.6 29.5 ± 19.1** 30.6 ± 21.6** 29.8 ± 15.6**
CK (mL · g−1 · min−1) 0.18 ± 0.10 0.09 ± 0.08 0.09 ± 0.07 0.64 ± 0.34** 0.45 ± 0.16** 0.39 ± 0.16**
FRK % 59.2 ± 17.1 66.0 ± 16.3 64.3 ± 23.7 56.7 ± 18.9 53.5 ± 14.3 57.0 ± 26.0
UNa/UK 0.08 ± 0.03 0.15 ± 0.13 0.12 ± 0.10 0.07 ± 0.04 0.10 ± 0.09 0.10 ± 0.10
TTKG 21 ± 7 17 ± 4* 16 ± 2* 17 ± 3 16 ± 3 16 ± 2**
CCl (μL · g−1 · min−1) 2.0 ± 1.0 1.2 ± 0.9 0.9 ± 0.5* 2.2 ± 1.0 2.5 ± 1.7 2.6 ± 1.5
FRCl % 99.51 ± 0.24 99.46 ± 0.33 99.31 ± 0.92* 99.29 ± 0.39 99.62 ± 1.82 99.15 ± 0.49**
COsm (μL · g−1 · min−1) 8.9 ± 1.3 4.6 ± 3.3* 4.2 ± 1.4* 10.1 ± 3.1 8.5 ± 3.3** 8.2 ± 1.9**
UOsm/POsm 1.9 ± 0.5 2.2 ± 0.8 2.2 ± 0.6 2.8 ± 1.2 2.7 ± 1.1 3.1 ± 1.2
CH2O (μL · g−1 · min−1) −5.1 ± 1.4 −3.1 ± 2.9 −2.3 ± 1.2 −6.9 ± 2.8 −5.7 ± 2.8 −5.6 ± 2.4**
  1. Data are mean ± SD. *p < 0.05 compared to C; **p < 0.05 compared to one week old lambs
  2. CX clearance of electrolyte X, FRX fractional reabsorption of electrolyte X, PRX proximal reabsorption of electrolyte X, DRX distal reabsorption of electrolyte X, UNa/UK urine Na+ to K+ ratio, TTKG transtubular K+ gradient, UOsm urinary osmolality, COsm clearance of osmoles, CH 2 O free water clearance
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BMC Physiology

ISSN: 1472-6793

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